长期COVID的神经表现的跨大陆比较分析
Millenia Jimenez1, Melissa Lopez1, Janet Miller1
1The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Frontiers in human neuroscience
|February 13, 2026
概括
SARS-CoV-2 感染后急性后续症 (Neuro-PASC) 的神经症状是全球性的,但症状负担和认知障碍因国家而异. 与尼日利亚和印度相比,美国和哥伦比亚的症状频率更高.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- SARS-CoV-2 感染 (PASC) 或长期COVID的急性后续症状呈现出各种神经学表现 (Neuro-PASC).
- 了解Neuro-PASC的全球变异对于公平的医疗保健至关重要. 这项研究考察了不同收入水平的国家的Neuro-PASC.
研究的目的:
- 为了比较人口统计,并发症,神经症状,生活质量和成年神经PASC患者的认知结果.
- 分析美国,哥伦比亚,尼日利亚和印度的Neuro-PASC演示的变化.
主要方法:
- 多国观测研究 (2020-2025) 涉及3,157名参与者,分为住院后的神经PASC (PNP) 或非住院的神经PASC (NNP).
- 认知评估使用了国家特定的工具:NIH工具箱,蒙特利尔认知评估或迷你精神状态检查.
- 采用多重对应分析来集群症状负担.
主要成果:
- 最常见的神经PASC症状包括脑雾,肌痛,头,头痛和感官障碍.
- 症状频率和认知障碍在不同国家有很大差异,美国和哥伦比亚的患病率更高.
- 症状负担集中在美国/哥伦比亚和尼日利亚/印度之间,这表明区域差异.
结论:
- 神经PASC是一种全球现象,但症状负担和心理困扰在区域上有所不同.
- 社会文化因素,医疗保健准入和诊断工具可能会影响观察到的变化.
- 在全球范围内,文化适应的查和COVID后护理策略至关重要.
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