在2型糖尿病中,默认模式网络的亚皮质核和皮质区域之间改变了静态和动态功能网络连接
Dongsheng Zhang1,2, Xiaoling Zhang2, Lei Wang3
1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Frontiers in neuroscience
|February 13, 2026
概括
2型糖尿病 (T2DM) 与改变的默认模式网络 (DMN) 连接有关,特别是涉及基底前脑 (BF). 较长的T2DM持续时间与DMN效率降低相关,影响认知功能.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 内分泌学 在内分泌学.
背景情况:
- 默认模式网络 (DMN) 功能连接 (FC) 的中断与2型糖尿病 (T2DM) 的认知障碍有关.
- 皮下核,如基础前脑 (BF) 和中背丘脑,对于DMN相关的认知至关重要,易受高血糖和胰岛素抵抗的影响.
- 在T2DM患者中,皮下区域和DMN皮层区域之间的特定FC模式及其认知关联尚未完全理解.
研究的目的:
- 在T2DM患者中,研究皮下核和DMN皮层区域之间的静止状态 (rs-FNC) 和动态 (dFNC) 功能连接.
- 探索改变FNC与T2DM认知障碍和临床参数的关联.
主要方法:
- 招募了82名T2DM患者和79名健康对照 (HC).
- 获得的临床数据,神经心理评估和休息状态功能磁共振成像 (rs-fMRI).
- 进行了rs-FNC和dFNC分析,随后与临床和认知数据进行了相关性分析.
主要成果:
- T2DM患者在BF和dorsomedial前额叶皮层 (dMPFC),BF和极之间,以及dMPFC和前额叶皮层之间的FC降低.
- 在T2DM中,dFNC揭示了变化的状态:低连接状态的频率/持续时间增加,高连接状态的频率/持续时间减少.
- 减少的dMPFC-BF FC与认知得分呈正相关,而改变的状态2连接性与T2DM持续时间呈负相关.
结论:
- T2DM持续时间与DMN连接效率降低有关.
- BF可以通过dMPFC调节认知功能.
- 这些发现突显了T2DM中DMN变化的时间和功能特异性,有助于理解认知功能障碍的神经机制.
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