三重乳液微流体核心贝水凝微囊用于口服氧fylline的交付:改善大肠炎和重新平衡肠道微生物群
Ji-Yeon Park1, Hye-Seon Jeong2, Seong-Ryeong Lim1
1Major of Human Bio-convergence, Division of Smart Healthcare, Pukyong National University, Busan, 48513, Republic of Korea.
Materials today. Bio
|February 13, 2026
概括
新的水凝微囊有效地将Pentoxifylline (PTX) 输送到结肠,减少炎症性肠病 (IBD) 的严重程度,恢复肠道微生物群平衡. 这种有针对性的方法增强了PTX.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD) 的特点是慢性胃肠炎症.
- 托西菲林 (PTX) 具有抗炎性质,但由于生物可用性和向性差,在IBD中临床使用有限.
- 需要有针对性的输送系统来提高PTX在IBD治疗中的有效性.
研究的目的:
- 开发适应pH值的水凝微囊,用于向向炎症结肠组织输送托西菲林 (PTX).
- 在IBD的小鼠模型中评估带有PTX的水凝微囊 (PHM) 的治疗疗效.
主要方法:
- 通过微流体和光聚合制造的核心水凝微囊 (PAA-PEGDA/PEGDA) 的制造.
- 由结肠环境触发的响应pH的药物释放机制的发展.
- 在硫酸 (DSS) 诱导的IBD小鼠中评估PHM疗效,测量疾病活性,组织学,炎症标志物和肠道微生物群组成.
主要成果:
- PHM显著降低了IBD疾病活动指数38.5%,恢复了粘膜架构,并减少了巨细胞透.
- PHM治疗抑制了关键的炎症性细胞因子 (IL-1β,IL-6,TNF-α) 分别为40%,66.2%和36.2%.
- PHM促进了肠道微生物群的稳态,恢复了诸如 Bacteroides acidifaciens 等有益的细菌.
结论:
- 响应pH的水凝微囊为IBD的向PTX输送提供了一个有效的策略.
- 在减轻IBD炎症和恢复肠道微生物平衡方面,PHM显示出显著的治疗潜力.
- 这种有针对性的药物输送系统为未来IBD干预提供了一个有希望的方法.
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