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一个婴儿患者的ABO不兼容移植病例
Cemile Pehlivanoğlu1,2, Sedat Ay3, Başak Akyollu4
1Division of Pediatric Nephrology, Department of Pediatrics, Koç University Hospital, Istanbul, Turkiye.
Pediatric transplantation
|February 13, 2026
概括
在婴儿的ABO不兼容移植 (ABOi-KT) 是可行的,而不是由于低异血凝素水平的广泛脱敏. 这种方法为面临器官短缺的儿科患者提供了安全有效的选择.
科学领域:
- 儿科脏病学 儿科脏病学
- 移植免疫学 移植免疫学
背景情况:
- 对ABO不兼容的脏移植 (ABOi-KT) 对于扩大捐赠池和解决器官短缺至关重要.
- 在儿童群体中越来越多地进行,以克服已故和相容的活体捐赠者的局限性.
研究的目的:
- 报告一个成功的ABOi脏移植在婴儿.
- 突出在婴儿早期没有广泛的先决条件的情况下,ABOi-KT的可行性.
主要方法:
- 一个6个月大的女孩患有末期脏疾病,接受活体捐赠者ABOi脏移植的病例报告.
- 移植前的抗体标位很低,并且没有进行预先调节治疗.
- 术后管理包括标准免疫抑制和支持性护理.
主要成果:
- 这名婴儿从她的祖母那里接受了脏移植.
- 患者在移植后逐渐恢复了移植功能.
- 手术后120天,功能保持良好,患者在临床上保持稳定.
结论:
- 婴儿期为ABOi-KT提供了一个独特的窗口,这是由于自然低的异血凝聚素水平,可能避免了广泛的脱敏协议.
- 对于经过精心挑选的婴儿和面临器官短缺的儿科患者来说,ABOi-KT是一种安全有效的选择.
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