国家查计划对唐氏综合征患病率和结果的影响
Cecilie Bryn Nordklev1,2, Denise Reis Costa3,4, Roy Miodini Nilsen5
1Fetal Medicine Centre, Oslo University Hospital, Oslo, Norway.
Acta obstetricia et gynecologica Scandinavica
|February 13, 2026
概括
对唐氏综合征 (DS) 的产前查改善了检测率和妊娠终止. 然而,DS的活胎和死胎率保持稳定,表明尽管有进展,但结果始终一致.
科学领域:
- 生殖医学是一种生殖医学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 对唐氏综合征 (DS) 的产前查随着技术进步而发展.
- 转向非侵入性产前检测的转变改变了查实践.
- 本研究评估了这些变化对DS怀孕结果的影响.
研究的目的:
- 评估改善的唐氏综合征 (DS) 产前查对怀孕结果的影响.
- 分析活产,死产和妊娠终止 (TOP) 的趋势.
- 确定影响有关TOP的决策的因素.
主要方法:
- 基于人口的登记册研究挪威怀孕 (19672021).
- 从1999年起对唐氏综合征 (DS) 诊断和终止怀孕 (TOP) 的分析.
- 用于评估时间趋势和人口统计学与TOP的关联的物流回归模型.
主要成果:
- 怀孕的发病率从0.165%增加到0.251% (1999-2021年).
- 产前检测率从18%上升到70%,而TOP比例从20%上升到55%.
- 对于DS的活产和死产率保持稳定;诊断后TOP比例为~80%.
结论:
- 产前检测和终止DS怀孕的数量显著增加.
- 尽管有进展,但持续怀孕的比例和DS的活产/死产的患病率仍然稳定.
- 母亲特征影响TOP决策,终结时平均妊娠年龄下降.
相关概念视频
Prevalence and Incidence
1.9K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
National Nursing Organizations I
3.1K
Nursing organizations assume a significant role in consistently developing the nursing profession through education, research studies, establishing practice standards, and reforming health policies. Typically, nursing organizations operate at the regional, national, and international levels. For example, the International Council of Nurses (ICN) represents more than 28 million nurses worldwide. In contrast, the American Nurses Association (ANA) is a membership organization representing nurses...
3.1K
National Nursing Organizations II
2.1K
Nursing organizations play a vital role in representing nurses working in specialized clinical settings, such as the American Association of Critical-Care Nurses (AACN).
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
2.1K
Predicting Reaction Outcomes
11.0K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Impact of Groups on Groups
262
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
262
Outcomes of Glycolysis
107.8K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.8K


