认知功能和活跃的炎症性肠病之间的双向关系
Bharati Kochar1,2,3, Adam S Faye4, Elizabeth Araka1
1Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.
在患有炎症性肠病 (IBD) 的老年人中,认知障碍很常见. 活性IBD与认知功能恶化有关,特别是延迟回忆,这突显了在这个人群中需要有效的IBD治疗的需要.
科学领域:
- 老年医学 老年医学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 认知障碍是一种显著的老年综合征,也是痴呆症的前体.
- 炎症性肠病 (IBD) 影响着越来越多的老年人群.
- 了解IBD老年人的认知功能对于早期检测和干预至关重要.
研究的目的:
- 描述60岁及以上的成年人被诊断患有IBD的认知功能.
- 研究IBD活动与认知功能之间的关联.
- 确定IBD患者认知能力下降的潜在早期查工具.
主要方法:
- 从六个美国中心招募了356名年龄≥60岁的IBD患者队列.
- 收集了人口统计数据,IBD病史,疾病活动指数和蒙特利尔认知评估 (MoCA).
- 多变量逻辑回归模型分析了一年内认知功能变化和IBD活动.
主要成果:
- 在基线时,42%的参与者对认知障碍的查结果呈阳性,延迟回忆和视觉空间功能缺陷是最常见的.
- 在一年内,31%的MoCA得分有所改善,19%的MoCA得分有所下降.
- 在基线时具有症状的IBD显著预测了随访时认知测试的恶化 (aOR:3.01).
结论:
- 在老年人中有效管理IBD对于减轻认知能力下降至关重要.
- 延迟回忆的缺陷,一个MoCA子域,与活跃的IBD有显著的关联.
- 延迟回忆可能成为老年IBD患者认知障碍的宝贵查工具.
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