饮酒的化学过程和酒者的社会行为模式
Lilian Oghenenyoreme Itoje-Akpokiniovo1, Prosper Uyoyou Irogbo1, Tayser Sumer Gaaz2
1Delta State University, Abraka, Nigeria.
酒精依赖涉及复杂的生化过程和社会因素. 了解这些相互作用对于酒精使用障碍 (AUD) 的综合预防和治疗策略至关重要.
科学领域:
- 生物化学 生物化学
- 神经科学是一个神经科学.
- 社会学 社会学 社会学
- 公共卫生 公共卫生
背景情况:
- 酒精消费对全球公共卫生和社会面临重大挑战.
- 酒精使用障碍 (AUD) 源于复杂的生化和社会文化相互作用.
研究的目的:
- 批判性地检查乙醇代谢途径及其与AUD患者社会行为的联系.
- 综合跨学科证据,将生化机制与神经化学适应和酒精使用的社会背景联系起来.
主要方法:
- 对同行评审文学进行跨学科的叙事审查.
- 综合生物化学,神经科学,心理学,社会学和公共卫生方面的证据.
主要成果:
- 通过酒精脱酶,脱酶和CYP2E1途径的乙醇代谢会影响中毒,耐受性,依赖性和危害性.
- 生物化学途径与神经化学适应 (GABAergic,glutamatergic,dopaminergic) 联系在一起,导致渴望,戒断和强迫性饮酒.
- 社会因素,包括学习,同行影响,压力,家庭和文化规范,显著塑造了与酒精有关的行为,特别是在像尼日利亚这样的低收入和中等收入环境中.
结论:
- 酒精依赖是一种多方面的疾病,包括生化障碍和社会嵌入现象.
- 预防,治疗和政策需要综合,文化响应的方法.
- 在对AUD的纵向,特定于背景和以非洲为中心的研究中存在差距.
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