连续化以以铁龙酸盐和顺序化以素对牙肉坏死牙中的细菌减少的有效性:双盲随机临床试验
Karthikeyan Anbalagan1, Amit Jena1, Luna Samanta2
1Department of Conservative Dentistry and Endodontics, Sriram Chandra Bhanja Dental College and Hospital, Utkal University, Odisha, India.
European endodontic journal
|February 13, 2026
概括
酸乙酸和酸盐灌有效地减少了死牙中的细菌,类似于传统的EDTA化. 这些药物显示出作为替代品的希望,尽管需要进一步的临床研究来验证.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 微生物学 微生物学
- 生物材料是一种生物材料.
背景情况:
- 纸死导致根通道的细菌感染.
- 有效的细菌减少对于内牙治疗成功至关重要.
- 探索新的灌剂对于改善内牙科结果至关重要.
研究的目的:
- 为了比较 etidronate 和 chitosan 作为根管灌剂对 EDTA 的疗效.
- 通过使用不同的化协议,评估牙中细菌减少与肉质死.
主要方法:
- 60名死牙患者通过被动超声波激活 (PUI) 进行了根管灌.
- 组分别接受了NaOCl/EDTA+PUI,NaOCl/etidronate+PUI,或NaOCl/chitosan+PUI. 这些组分别接受了NaOCl/EDTA+PUI,NaOCl/etidronate+PUI,或NaOCl/chitosan+PUI.
- 在治疗前和治疗后使用16S rRNA基因qPCR量化了细菌数量.
主要成果:
- 所有的灌方案都显著降低了细菌数量 (p<0.001).
- 平均细菌减少率为97.7% (EDTA),96.3% (乙二酸) 和96.8% (奇托桑).
- 在这三个组中,没有观察到细菌减少的显著差异 (p=0.345).
结论:
- 伊蒂德罗纳酸和奇托桑在减少根运河细菌方面表现出与EDTA相似的疗效.
- 这些药物是EDTA的潜在替代品,用于灌死的牙.
- 需要进行进一步的临床试验,以证实 etidronate 和 chitosan 的临床适用性.
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