在前列腺活检前的直肠抹布上,诺基诺抗性的危险因素
Conor B Driscoll1, Mitchell M Huang1, Nicole Handa1
1Northwestern University, Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA.
Urology practice
|February 13, 2026
概括
在接受前列腺注射活检 (PNB) 的患者中,诺抗性 (FQR) 保持稳定,但与以前的FQ暴露和某些人口统计学因素有关. 识别这些患者层面的FQR风险可以改善活检前的咨询,并降低尿路塞普斯风险.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 前列腺癌的诊断通常涉及前列腺针活检 (PNB).
- 使用抗生素,包括诺基诺 (FQs) 的活检前预防,旨在预防PNB后泌尿失效.
- 诺基诺耐药性 (FQR) 的上升需要更新风险评估.
研究的目的:
- 评估在多医院系统内接受PNB的患者的FQR趋势.
- 确定与FQR相关的患者级风险因素.
主要方法:
- 对10372名患者进行了回顾性队列研究,从2013年至2024年接受了PNB前直肠扫描.
- 收集的数据包括人口统计,并发症和以前的FQ暴露.
- 用多变量回归分析来确定FQR风险因素.
主要成果:
- 总体FQR率为18.8%,其中大肠杆菌是最常见的耐药细菌.
- 在整个研究期间 (2013-2024年) 的FQR率保持稳定.
- 患者层面的FQR风险因素包括:以前的FQ暴露,年龄较大,没有保险的身份,西班牙裔种族,非白人种族,以及膜炎史.
结论:
- 确定了FQR的新型患者级风险因素,包括先前的FQ暴露,年龄,保险状况,种族,种族和尾炎史.
- 目前美国泌尿器官协会 (AUA) 的指导方针可能需要改进,以对FQR进行全面的PNB前咨询.
- 需要进一步的研究来更新临床指南,以管理PNB之前的FQR风险.
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