在疹中使用NSAIDs 疹感染和中风风险:全国性的案例交叉研究
Lin-Chieh Meng1,2,3, Hsi-Yu Lai1,4, Hui-Min Chuang1,2
1Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Linsen S. Rd, Taipei, 10050, Taiwan.
Drug safety
|February 13, 2026
概括
疹疹 (HZ) 感染与非类固醇抗炎药物 (NSAID) 使用相结合,可显著增加中风风险,特别是在老年人和患有并发症的人群中. 在HZ期间优化疼痛管理对于减少中风发病率至关重要.
科学领域:
- 流行病学 流行病学
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
背景情况:
- 热带疹 (HZ) 和长期使用非类固醇抗炎药物 (NSAID) 是已知的心血管疾病风险因素.
- 有限的证据表明,HZ和NSAID使用对中风风险的结合作用有限.
研究的目的:
- 调查HZ感染,同时使用NSAID和中风发病率之间的关联.
- 分析这些因素对中风亚型和特定患者人口统计学的影响.
主要方法:
- 在台湾 (2014-2020年) 使用医疗保险数据进行了一项全国性基于人口的队列研究.
- 一个案例交叉设计,比较焦点期 (中风前1-30天) 和参考期 (中风前366-395天) 的暴露.
- 条件后勤回归用于估计中风风险的调整几率比率 (aORs).
主要成果:
- 结合HZ和NSAID使用将中风风险增加一倍 (aOR2.05).
- 观察到缺血性中风 (aOR 1.94),出血性中风 (aOR 1.81) 和TIA (aOR 2.81) 的显著风险增加.
- 在65岁以上的个体,免疫力低下的患者和患有脏疾病的患者中,注意到风险增加.
结论:
- 肝炎感染和NSAID使用对中风具有显著的联合风险.
- 老年人和患有特定并发病的人群的风险特别高.
- 在HZ发作期间优化疼痛管理对于减轻中风风险至关重要.
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