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病 - 淋巴瘤综合征中的脏参与:两例病例的报告
Siarhei Dzedzik1, Ilya Glezerman2,3, Andrew D Zelenetz2,3
1New York-Presbyterian/Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA. sd10326@hsc.wvu.edu.
CEN case reports
|February 13, 2026
概括
沙性淋巴瘤综合征可能涉及脏. 研究人员在患有慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的患者中发现了粒状间歇性炎,即使没有直接透脏中的癌细胞.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 沙尔科毒症 - 淋巴瘤综合征将沙尔科毒症与淋巴瘤瘤联系在一起.
- 已知慢性淋巴细胞白血病/小淋巴细胞淋巴瘤 (CLL/SLL),通常在癌细胞附近.
- 没有先前的报告详细介绍了脏颗粒状间歇性炎,没有同时发生的CLL/SLL透.
研究的目的:
- 在患有CLL/SLL但没有直接瘤透的患者中报告脏中颗粒状间歇性炎病例.
- 为了突出 Sarcoidosis-lymphoma 综合征中脏参与的独特表现.
主要方法:
- 两名患有CLL/SLL的患者的病例报告呈现急性损伤 (AKI).
- 脏活检分析以确定AKI的原因.
- 审查放射性发现,包括淋巴腺病变.
主要成果:
- 两位患者都有AKI和广泛的淋巴腺病变.
- 脏活检出乎意料地揭示了扩散型粒状间歇性炎,没有CLL/SLL的证据.
- 患者接受了免疫抑制和/或克隆导向疗法.
结论:
- 呈现了第一个组织学证实的细粒状间歇性炎病例在脏中,同时没有CLL/SLL透.
- 证明粒状间歇性炎可以在CLL/SLL患者中发生,而不依赖于直接的瘤透.
- 用免疫抑制剂/克隆导向疗法的治疗改善了这些患者的功能.
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