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Updated: Feb 14, 2026

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在接受底内镜手术的老年人中嗅觉脆弱性:从嗅觉带升高的洞察力
J Kim1,2, C-S Rhee2,3, I K Choi3
1Obstructive Upper Airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, South Korea.
Rhinology
|February 13, 2026
概括
年龄较大的患者 (≥50岁) 在内镜内鼻接近 (EEA) 后经历了更糟糕的气味结果. 年龄会影响嗅觉细胞,但更高的S100表达可能会改善术后的嗅觉.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 手术后的嗅觉功能障碍是内镜内道方法 (EEA) 的已知并发症.
- 根据EEA,患者年龄对嗅觉结果的具体影响仍然不清楚.
- 本研究研究了年龄作为EEA后嗅觉恢复的一个因素,包括嗅觉粘膜组织学分析.
研究的目的:
- 为了确定患者的年龄是否影响内镜内道方法 (EEA) 后的嗅觉结果.
- 检查嗅觉粘膜组织学的与年龄相关的变化.
- 为了将组织学发现与术后嗅觉功能相关联.
主要方法:
- 对接受EEA治疗的患者进行回顾性审查,以检查具有嗅带升高的细胞/细胞瘤.
- 在术前和术后6个月使用跨文化嗅觉识别测试 (CCSIT) 和韩国嗅觉问卷 (OQ) 评估了嗅觉功能.
- 嗅觉粘膜对水平基底细胞 (HBC),嗅觉神经元 (OSN) 和嗅觉吸收细胞 (OEC) 的免疫组化学分析.
主要成果:
- 分析了43名患者 (平均年龄为53.7岁),显示手术后的CCSIT和OQ得分有所下降.
- 50岁及以上的患者的嗅觉功能显著降低 (低于CCSIT和OQ).
- 年龄的增加与减少的OSN数量,HBC数量以及嗅觉粘膜中的S100表达强度相关. S100表达与嗅觉结果正相关.
结论:
- 年龄≥50岁与EEA后嗅觉功能的更大下降有关,嗅觉带的升高.
- 晚年与关键的嗅觉细胞 (OSNs,HBCs) 的水平降低有关.
- 嗅觉粘膜中S100表达的升高预测了手术后更好的嗅觉结果.
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