对电位计微针传感器实施杀菌和消毒协议:安全声明的要求
Xue Hui1, Agueda Molinero-Fernandez1, Ruben Zapata-Pérez2
1UCAM-SENS, Universidad Católica San Antonio de Murcia, UCAM HiTech, Avda. Andres Hernandez Ros 1, Murcia 30107, Spain.
ACS sensors
|February 13, 2026
概括
用于临床前研究的微针 (MN) 传感器可以使用乙醇或UV-C可靠地灭菌,确保生物安全性和分析准确性. 然而,自闭塞会损坏这些传感器,使它们不适合消毒.
科学领域:
- 生物医学工程 生物医学工程
- 传感器技术 传感器技术
- 杀菌和消毒是消毒和消毒的过程.
背景情况:
- 微针 (MN) 传感器为疾病监测和临床前研究提供了潜力.
- 通过有效的灭菌来确保生物安全对于MN传感器应用至关重要.
- MN传感器与标准杀菌方法的兼容性在很大程度上没有得到研究.
研究的目的:
- 系统地评估电位计MN传感器与常见实验室灭菌和消毒协议的兼容性.
- 评估乙醇,自和UV-C暴露对MN传感器分析性能和生物安全性的影响.
- 验证用于临床前使用的MN传感器的有效杀菌方法.
主要方法:
- 电位计pH-MN传感器 (使用三基胺离子体和聚乙烯丁-Ag/AgCl参考电极) 经过乙醇处理,自,并暴露于UV-C.
- 通过测量校准参数 (斜率,标准电位) 和传感器精度来评估分析性能.
- 微生物分析评估了乙醇和UV-C在消除细菌污染方面的有效性.
主要成果:
- 乙醇治疗维持了接近Nernstian的反应和传感器精度 (<5%的偏差).
- 自锁严重损害了MN传感器的完整性和性能.
- 优化UV-C暴露 (两步协议) 保持了传感器准确性 (<4%偏差),乙醇和UV-C都有效消除了细菌污染.
结论:
- 乙醇和UV-C是电位计MN传感器的合适灭菌方法,可确保预临床应用的分析可靠性和生物安全性.
- 自动封闭与测试的MN传感器设计不兼容.
- 建立了一个系统验证工作流程,以评估MN传感器的灭菌兼容性.
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