父亲怀孕前健康对出生缺陷和头周的影响:一个范围审查
Cindy-Lee Dennis1,2,3, Karen McQueen4, Justine Dol5
1Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada.
PLOS global public health
|February 13, 2026
概括
怀孕前的父亲健康,物质使用和环境暴露对胎儿发育有重大影响,包括先天性出生缺陷和头周. 包括父亲在怀孕前护理中对于改善生殖和新生儿结果至关重要.
科学领域:
- 生殖健康 生殖健康
- 发育生物学 发展生物学
- 环境健康 环境健康
背景情况:
- 父亲的预先概念暴露和生活方式因素会影响精子表观遗传学和胎儿发育.
- 对父亲对胎儿发育的影响,特别是先天性出生缺陷 (CBD) 和头周长的研究是有限的.
- 了解父亲的贡献对于全面的孕前健康策略至关重要.
研究的目的:
- 进行一项关于父亲孕前健康的文学综合范围审查.
- 分析父亲因素对胎儿发育的影响,特别是CBD和头周长.
- 确定这一研究领域的知识差距和方法限制.
主要方法:
- 根据乔安娜·布里格斯研究所的方法论和公布的协议进行范围审查.
- 搜索了五个数据库,寻找关于父亲预孕期和CBD和头周长结果的研究.
- 包括48项研究,数据由两位使用Covidence的独立审稿人提取.
主要成果:
- 几个与CBD相关的父亲因素:身体健康 (代谢综合征,感染,癌症),吸烟,酒精和环境暴露 (溶剂,金属,农药).
- 甲福明和泽被确定为CBD的潜在药物风险;大多数其他药物没有增加风险.
- 关于头周长的有限数据表明存在潜在的关系,但由于研究数量较少,这些发现并不广泛适用.
结论:
- 父亲的先发性健康状况,物质使用,环境因素和某些药物显著影响后代的先天性缺陷和头周.
- 扩大预孕咨询和预防策略必须明确包括父亲.
- 纳入父亲健康对于理解机制,减少先天性风险,改善生殖/新生儿结果至关重要.
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