轨道和周围状细胞癌中的PD-1抑制剂:一篇评论
Elana Meer1,2, Alythia Vo3, Michelle Zhang1
1Department of Ophthalmology.
Ophthalmic plastic and reconstructive surgery
|February 13, 2026
概括
编程细胞死亡蛋白-1 (PD-1) 抑制剂在周眼和轨道皮肤状细胞癌 (cSCC) 中表现出显著的疗效和安全性,为手术提供了一个节省全球的替代方案.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 周眼和轨道皮肤状细胞癌 (cSCC) 由于靠近重要结构而存在治疗挑战.
- 传统的治疗方法,如手术和放射治疗,可以导致显著的发病率,包括轨道外.
研究的目的:
- 系统地审查编程细胞死亡蛋白-1 (PD-1) 抑制剂对周期性和轨道性cSCC的临床应用,疗效和安全性.
- 评估PD-1抑制剂作为该地区高级和耐火性cSCC的新疗法.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在2025年6月进行了主要数据库 (PubMed,科学网,Embase,Cochrane Central) 的搜索.
- 从病例报告,病例系列和临床试验中提取和分析数据.
主要成果:
- 在33项研究中,102名患者接受了PD-1抑制剂 (cemiplimab, pembrolizumab).
- 52%的患者实现了完全反应,34%的患者实现了部分反应;7%的患者患有稳定性疾病,7%的患者患有进展性疾病.
- 副作用通常是可以管理的,疲劳,腹和皮疹是最常见的.
结论:
- PD-1 抑制剂对周期性和轨道cSCC具有强烈的疗效和可接受的安全性.
- 这些物质代表了一个潜在的节省地球的替代轨道化.
- 进一步的研究是有必要的,以优化治疗选择和时间.
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