眼香和心血管结果:一个倾向匹配的分析
Niloufar Bineshfar1,2, Gabriella Schmuter3, Jaffer Shah3
1Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Ophthalmic plastic and reconstructive surgery
|February 13, 2026
概括
桑泰拉斯马palpebrarum (XP) 与高脂血症和心血管事件的风险更高有关. 早期发现XP可能有助于评估心血管风险.
科学领域:
- 皮肤病学 皮肤病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 桑泰拉斯马 palpebrarum (XP) 是一个常见的周期性病变.
- 它与系统性脂质失调和心血管疾病的关联是有争议的.
- 这项研究调查了XP和心血管结果之间的联系.
研究的目的:
- 评估XP,脱脂症和主要心血管结果之间的关系.
- 使用大规模的电子健康记录数据集.
- 评估XP提出的心血管风险分层机会.
主要方法:
- 追溯性倾向得分匹配的队列研究.
- 使用了TriNetX.X的非识别电子健康记录.
- 匹配了20 048例XP病例与20 048名年龄在20-85岁之间的对照.
- 分析了高脂血症和主要不良心血管事件 (MACE) 的发生率.
主要成果:
- XP患者的超脂血症 (32.2%对27.6%) 和MACE (13.0%对11.4%) 的比率更高.
- 考克斯模型显示,XP患者的高脂血症 (HR: 1.38) 和MACE (HR: 1.26) 的风险增加.
- 观察到所有原因死亡率的小,统计学上显著增加 (HR:1.09).
结论:
- XP显著与动脉质脂质样本和心血管事件风险增加有关.
- XP与较多使用降脂药物相关.
- 识别XP可以促进早期心血管风险分层.
相关概念视频
Sign Test for Matched Pairs
432
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
To conduct the sign test, we first calculate the differences in...
432
Predicting Reaction Outcomes
11.0K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Outcomes of Glycolysis
107.8K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.8K
Overview of the Cardiovascular System
12.3K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
12.3K
Wilcoxon Signed-Ranks Test for Matched Pairs
507
The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
507
Regulation of the Cardiovascular System
4.2K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.2K


