在被评估为疑似多发性硬化症的患者中,对2024麦当劳标准的表现
Wallace J Brownlee1,2, Davide Maccarrone1,3, Riccardo Nistri1,4
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom.
Neurology
|February 13, 2026
概括
与2017年标准相比,2024年麦当劳标准可以更早,更频繁地诊断多发性硬化症 (MS). 这种经过修订的诊断方法在所有年龄组中显示出一致的表现.
科学领域:
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 2024年麦当劳标准更新了多发性硬化症 (MS) 的诊断建议.
- 在现实临床实践中验证这些新标准至关重要.
研究的目的:
- 评估2024麦克唐纳标准的应用和诊断性能.
- 在怀疑MS的患者中,将2024年的标准与2017年的标准进行比较.
主要方法:
- 在2024年1月至12月期间评估的疑似多发性硬化症患者的回顾性分析.
- 2017年 (前性) 和2024年 (追溯性) 麦当劳标准的应用.
- 两组标准之间的MS诊断率和诊断时间的比较.
主要成果:
- 2024年标准诊断出更多的MS患者早于2017年标准 (220对172最初;237对204随访).
- 根据2024年标准,诊断的中位时间显著减少 (40天 vs 84天).
- 2024年标准显示高灵敏度 (92.6%) 和准确度 (83.6%),但对MS诊断具有中等特异性 (57.8%).
结论:
- 2024年麦当劳标准有助于更早,更频繁地诊断多发性硬化症,包括放射性隔离综合征.
- 对修订后的标准的表现在儿童和成人群体中是一致的.
- 局限性包括缺乏特定生物标志物和视神经评估的数据.
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