诱导电流对功能磁共振成像在单极深度大脑刺激期间的解释性产生影响
Chengyuan Wu1,2, Stephen Slovensky1,2, Mahdi Alizadeh1,2
11Department of Neurosurgery, Thomas Jefferson University, Philadelphia.
Journal of neurosurgery
|February 13, 2026
概括
磁共振成像 (MRI) 在单极模式下显著扭曲深度大脑刺激 (DBS) 电流,影响功能性MRI (fMRI) 解释. 双极性配置保持稳定的电流,证明在DBS期间可靠的fMRI数据至关重要.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 生物医学工程 生物医学工程
背景情况:
- 深度大脑刺激 (DBS) 是一种治疗干预.
- 功能磁共振成像 (fMRI) 用于评估大脑活动.
- 同时的MRI和DBS引发了对设备稳定性和数据完整性的担忧.
研究的目的:
- 在MRI扫描期间评估DBS电流的稳定性.
- 为了确定MRI诱导的电流变化是否会影响fMRI的解释性.
- 为了比较单极和双极DBS配置之间的电流稳定性.
主要方法:
- 两个电流控制的DBS系统在3TMRI期间在一个幻影中进行了测试.
- 刺激被应用在单极和双极模式,无论是开启还是关闭.
- 诱导电流使用MRI条件设置在各种序列中测量,包括fMRI协议.
主要成果:
- 在MRI期间,单极DBS表现出显著的电流波动 (-3.2到+3.9mA) 和极性反转,特别是在fMRI序列期间.
- 双极性DBS表现出稳定的输出,与编程参数的偏差最小.
- 单极输出的变化在整个系统中是一致的,而不是由于阻抗变化.
结论:
- 核磁共振诱导的电流大大改变单极DBS输出,危及并发的fMRI数据.
- 在单极DBS期间观察到的血氧水平依赖 (BOLD) 反应可能反映出扭曲的刺激.
- 建议采用双极性DBS配置,以避免混效应,并确保在刺激期间准确的fMRI解释.
关键词:
磁力共振成像安全 磁力共振成像安全二极性刺激是双极性刺激.功能性磁共振成像技术 功能性磁共振成像技术诱导电流的诱导电流是什么单极刺激是一种单极刺激.深度大脑刺激 刺激大脑诊断技术 诊断技术 诊断技术功能神经外科 功能神经外科更多相关视频
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