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The Extracellular Matrix01:42

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The Extracellular Matrix01:29

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
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Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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高活性99Mo微树脂制造,用于分毫米SPECT系统采集矩阵.

Tiantian Dai1, Qingyang Wei2, Yuhang Qiu3

  • 1Department of Radiation Oncology, China-Japan Friendship Hospital, China-Japan Friendship Hospital‌ ‌2 Yinghuayuan East Street, Chaoyang District, Beijing, Beijing, 100029, China.

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我们开发了一种新的混合99Mo/99mTc点源,用于临床前单光子发射计算机断层扫描 (SPECT) 成像. 这种新方法可以为高分辨率的SPECT系统进行准确的系统矩阵校准.

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斯佩克特 (Spectre) 是一个运动场.高分辨率的高分辨率解决方案离子交换树脂 离子交换树脂99-99是一种.系统矩阵是一个系统矩阵.

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科学领域:

  • 医疗成像医学成像
  • 核医学是一种核医学.
  • 临床前研究 临床前研究

背景情况:

  • 单光子发射计算断层扫描 (SPECT) 对于临床前分子成像至关重要.
  • 准确的系统矩阵对于高质量的SPECT图像重建至关重要.
  • 目前使用99mTc的方法由于其短半衰期存在局限性,使长时间的获取复杂化.

研究的目的:

  • 开发一种可发电机生产的混合99Mo/99mTc点源,用于改进SPECT系统矩阵校准.
  • 为了克服短暂的99mTc的局限性,为了延长获取时间.
  • 为了促进高分辨率SPECT系统的准确和可重现的校准.

主要方法:

  • 创建了一个混合99Mo/99mTc点源,使用99Mo吸附在AG1-X8树脂微球上.
  • 每个珠的高活性 (>10 mCi).
  • 在两个SPECT平台上进行蒙特卡罗模拟,以评估99Mo污染的影响.

主要成果:

  • 混合源提供高活性,有效使用半衰期更长.
  • 蒙特卡洛模拟显示,99Mo高能光子对99mTc系统矩阵测量的影响微不足道.
  • 源强度足以进行100×100×100的系统矩阵采集.

结论:

  • 在最先进的SPECT中引入了一种用于准确,可重复的系统矩阵校准的实用方法.
  • 混合99Mo/99mTc源支持开发高分辨率的SPECT系统.
  • 通过可靠的校准来确保一致的成像性能.