新的抗结核前胺类同类物作为聚合物微粒中的强有力的有效载荷:利用斑马鱼试验来加速优化

Andrew M Thompson1, Nils-Jørgen K Dal2, Francesca Boldrin3

  • 1Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

概括

新的普雷托曼尼德衍生物在治疗结核病和相关感染方面表现有前途. 模拟剂14在斑马鱼模型中显示出强大的疗效和安全性,在小鼠中表现出极好的口服生物可用性.

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