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下肢强度不对称及其与多发性硬化症患者的功能变化相关

Callie Evanchick¹, Nicholas Lopez¹, Elizabeth S Gromisch²

¹Mercy University, 555 Broadway, Dobbs Ferry, NY, USA.

Multiple sclerosis and related disorders

|February 13, 2026

概括

下肢强度不对称,特别是在膝盖曲和脚背曲方面,显著影响了MS (PwMS) 患者的功能状态. 特定的不对称性切线,特别是膝盖曲,预测PwMS的功能下降.

科学领域:

神经学神经学
康复科学康复科学康复科学
生物医学工程生物医学工程

背景情况:

下肢 (LL) 非对称性与MS (PwMS) 患者的疲劳,不稳定性和跌倒恐惧有关.
关于LL强度不对称对PwMS功能状态变化的具体贡献的研究有限.

研究的目的:

在PwMS中调查在PwMS中的各种功能状态组中LL强度不对称性的差异.
为了确定特定的不对称性得分,表明PwMS中的功能状态变化.

主要方法:

一项横截面研究分析了183个PwMS的数据,这些数据使用MS步行量表 (MSWS-12) 将其分为功能组.
测量了峰值同度扭矩和关节绑架/延伸/屈曲,膝盖延伸/屈曲和脚脚下屈曲/背部屈曲的不对称性.
统计分析包括检查功能组之间的差异和执行接收器操作特征 (ROC) 分析,以确定不对称性的最佳切断分数.

主要成果:

在功能组之间观察到膝盖曲 (KF),脚背曲 (ADF) 和膝盖延伸 (KE) 非对称性的显著差异.
基因纤维不对称 (切线≥19.74%) 和ADF不对称 (切线≥14.29%) 显示出临床相关的敏感性和特异性.
在PwMS中,KF不对称性成为功能状态的重要预测因素 (aOR:264.75).

结论:

只有KE,KF和ADF不对称性在PwMS的功能水平之间显示出显著的差异.
从最小到严重的功能组区分的不对称值超过了传统的10%标准.
KF不对称性是功能变化的关键预测因素,突出显示了它在管理PwMS中的重要性.

关键词:

不对称的不对称性功能功能功能功能下肢的下肢是什么意思下肢的下肢是什么意思多发性硬化症是多发性硬化症.肌肉力量肌肉力量是指肌肉的力量.

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