类黄酸富含的牛奶可以保护小鼠免受肠道氧化应激和屏障功能障碍
Yingrui He1, Yigeng Qin1, Wenjun Xu1
1Beijing Key Laboratory of Dairy Cow Nutrition, College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China.
Food chemistry
|February 13, 2026
概括
奶牛中的类黄酸盐提取物 (CFE) 丰富了牛奶的有益化合物,增强了其抗氧化和肠道保护性质. 这种强化牛奶显示出作为功能性乳制品改善健康的承诺.
科学领域:
- 乳制品科学 乳制品科学
- 营养生物化学 营养生物化学
- 胃肠病学 胃肠病学
背景情况:
- 饮食中的黄类化合物对健康有好处,但它们的转移到牛奶和随后的影响需要进一步研究.
- 类黄素提取物 (CFE) 富含具有已知的抗氧化特性的生物活性化合物.
- 了解CFE对牛奶成分和宿主肠道健康的影响对于开发功能性食品至关重要.
研究的目的:
- 为了确定饮食中CFE补充剂对奶牛对牛奶中黄酸含量和抗氧化能力的影响.
- 在小鼠模型中评估富含CFE的牛奶对肠道氧化应激和炎症的保护作用.
- 调查CFE丰富的牛奶对肠道微生物群组成和肠道屏障功能的影响.
主要方法:
- 奶牛每天补充150克CFE,并分析牛奶的和黄酸含量.
- 一种用脂聚糖 (LPS) 挑战的小鼠模型被用来评估富含CFE的牛奶对氧化应激和炎症的影响.
- 分析了肠道微生物群的组成,肠道形态和与抗氧化剂和紧密结路相关的基因表达.
主要成果:
- 补充CFE显著增加了牛奶的黄酸盐 (hesperidin,narirutin,naringin,nobiletin,tangeretin) 和总含量,增强了牛奶的抗氧化能力.
- 在受挑战的小鼠中,富含CFE的牛奶改善了抗氧化酶活动,减少了炎症性细胞因子,并上调了Nrf2/HO-1/NQO1通路基因表达.
- 肠道形态恢复,杯状细胞的丰富性增加,肠道微生物群转向有益的种类 (乳酸菌,细菌) 减少有害的属 (Desulfovibrio).
结论:
- 食CFE补充剂有效丰富牛奶的生物活性黄酸,并增强其抗氧化潜力.
- 用CFE强化牛奶在体内表现出显著的抗氧化,抗炎和肠道保护作用.
- 用类黄酸盐强化的牛奶具有作为促进肠道健康的功能性乳制品的潜力.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.9K
09:23Specific and Accurate Detection of the Citrus Greening Pathogen Candidatus liberibacter spp. Using Conventional PCR on Citrus Leaf Tissue Samples
Published on: June 29, 2018
8.3K
相关概念视频
Oxidation Numbers
43.3K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
43.3K
Anatomy of the Intestines
88.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
88.0K
Pyruvate Oxidation
169.5K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
169.5K
Responses to Salt Stress
14.7K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.7K
Oxidation-Reduction Reactions
75.9K
Oxidation–Reduction Reactions
75.9K
Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
