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肠道微生物群影响老化小鼠的药理动力学变化:影响因药物而异

Qing-Xuan Xie1, Xiao-Na Zeng1, Yun-Hui Wang1

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; FuRong Laboratory, Changsha, Hunan, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.

Drug metabolism and disposition: the biological fate of chemicals
|February 13, 2026
PubMed
概括

肠道微生物群对老年小鼠的药物代谢有显著影响,影响了甲和米达佐拉姆的暴露. 清除肠道微生物逆转了与年龄相关的德克斯特罗梅多芬暴露的变化,有助于个性化老年药物治疗.

关键词:
衰老的衰老 衰老的衰老我们的肠道微生物群.个性化医疗是个性化的医疗.药物动力学的变化

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