开启卡佩奇他后的血管静脉炎:一种罕见但严重的心脏毒性作用
Sergio Ponce Simal1, Mario Martínez Fleta1, Maria Prados Arnedo1
1Department of Cardiology, Miguel Servet University Hospital, Zaragoza, Spain.
The Journal of emergency medicine
|February 13, 2026
概括
紧急医生应考虑胸痛患者的capecitabine诱导心脏毒性. 早期识别这种化疗副作用和及时的血管扩展剂治疗对于患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 紧急医疗 紧急医疗
背景情况:
- 包括capecitabine在内的甲胺是对结直肠癌等固体瘤的重要化疗剂.
- 冠状动脉是已知的5-fluorouracil (5-FU) 的心脏毒性作用,这是capecitabine的一个组成部分.
- 卡佩西塔的心血管副作用不太明确,需要提高认识.
研究的目的:
- 要突出capecitabine诱导心脏毒性的潜力,特别是血管节性心痛.
- 告知急诊医生如何识别和管理这种不良事件.
主要方法:
- 一个66岁的男性患有直肠腺癌,接受capecitabine治疗,胸部疼痛的病例报告.
- 诊断评估包括心电图,冠状动脉血管学和乙胆诱导试验.
- 治疗包括停止使用capecitabine和血管扩展剂治疗.
主要成果:
- 患者在开始服用capecitabine后经历了胸部疼痛和ECG变化与血管一致.
- 冠状动脉扫描显示没有阻塞性疾病,但乙胆刺激证实了血管节性心痛.
- 用尼甘缓解了症状,在停止服用capecitabine并进行医疗管理后,患者的情况有所改善.
结论:
- 卡佩奇他可以导致血管性心痛,即使在没有传统心脏风险因素的患者中也是如此.
- 紧急医生必须考虑capecitabine诱导的心脏毒性患者呈现胸痛.
- 及时识别,药物戒断和血管扩展剂治疗是管理这种瘤紧急情况的关键.
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