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针对接受血液性恶性瘤化疗的老年人进行个性化体力活动计划
Baptiste Fournier1, Chiara Russo2, Aurélia Maire3
1Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France; Radiation: Defense, Health, Environment, INSERM UMR1296, Lyon, France.
Journal of geriatric oncology
|February 13, 2026
概括
对接受化疗的急性髓性白血病 (AML) 和非霍奇金淋巴瘤 (NHL) 的老年人来说,个性化体育活动计划是可行的和安全的. 患者表现出改善的行走耐力和生活质量.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 运动生理学 运动生理学
背景情况:
- 患有血液性恶性瘤的老年人在癌症治疗期间面临功能衰退的高风险.
- 身体活动 (PA) 可能减轻这些影响,但急性髓性白血病 (AML) 和非霍奇金淋巴瘤 (NHL) 患者的证据有限.
研究的目的:
- 评估在老年AML/NHL患者的化疗期间和之后6个月个性化PA计划的可行性和探索性影响.
- 评估程序的遵守,招聘,保留,安全和患者满意度.
主要方法:
- 瘤老年和个性化身体活动 (OCAPI) 研究是一项单臂前性可行性研究.
- 患有AML/NHL的参与者 (≥65岁) 接受了为期6个月的个性化PA计划,包括监督/无监督的会议,活动追踪器和激励电话.
- 结果包括坚持,可行性指标,身体状况,PA行为以及患者报告/老年患者的结果.
主要成果:
- 招聘和保留率分别为59%和88%;监督会议的遵守率为66%.
- 没有运动相关的不良事件发生,患者满意度很高 (96%).
- 在走路耐力 (+53米,6分钟步行测试) 和六个月后的生活质量方面观察到显著改善;手握力下降.
结论:
- 个性化的PA计划证明了AML/NHL患者接受化疗的可行性和安全性.
- 探索性发现表明,改善了行走耐力和生活质量,具有诊断特定的功能轨迹.
- 建议进行更大的多中心试验,以确认这些初步结果.
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