环境标准限量化物暴露在斑马鱼幼虫中优先考虑神经毒性而不是骨毒性:基准剂量分析
Xiumei Yang1, Xianmei Zhang1, Guojun Jian1
1School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, China.
Aquatic toxicology (Amsterdam, Netherlands)
|February 13, 2026
概括
饮用水中的化物存在神经发育风险. 斑马鱼幼虫研究表明,即使度低,中枢神经系统 (CNS) 对化物比骨更敏感.
科学领域:
- 环境毒理学环境毒理学
- 神经发育生物学 神经发育生物学
- 斑马鱼模型的模型
背景情况:
- 化物是一种常见的环境污染物.
- 目前的水标准侧重于骨毒性,可能忽视神经发育风险.
- 与骨系统相比,中枢神经系统 (CNS) 对化物的敏感性在环境相关的度下尚不清楚.
研究的目的:
- 直接比较中枢神经系统和骨系统对斑马鱼幼虫化物暴露的敏感性.
- 评估与跨越国际监管限制的化物度相关的神经发育风险.
- 确定当前的水标准是否充分保护神经发育效应.
主要方法:
- 斑马鱼幼虫暴露于化物度在0.5至20.0毫克/升之间.
- 采用了一种综合方法,结合了行为分析,转录学和基准剂量建模.
- 测量了大脑中的化物积累和骨矿化变化.
- 分析了关键神经和骨标记物的表达.
主要成果:
- 化物以剂量依赖的方式在大脑中积累.
- 在0.5 mg/L时观察到神经刺激 (超位运动),而骨效应 (矿化减少) 仅在20.0 mg/L时才发生.
- 转录组分析显示,与骨途径相比,中枢神经系统途径的参与范围更广泛.
- 基准剂量建模表明,中枢神经系统受到影响的度比骨系统低 (0.17 mg/L对比1.83 mg/L).
结论:
- 发育中的中枢神经系统是对化物显著更敏感的目标,而不是在监管暴露水平的骨架.
- 目前基于骨毒性的水质标准可能无法充分保护神经发育效应.
- 需要进一步的研究来将生物标志物发现转化为功能健康结果.
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