重金属的毒性与微量元素的毒性保护妇女的生殖健康 - - 一个系统的审查
A Amanzholkyzy1, Y Sagidanova1, E Stankevicius2
11Department of Normal Physiology, «West Kazakhstan Marat Ospanov Medical University» NSJC, Aktobe, the Republic of Kazakhstan.
Georgian medical news
|February 13, 2026
概括
环境重金属暴露,包括,和,与女性生殖问题,如PCOS和子宫内膜异位症有关. 保持和等微量元素的平衡对于生殖健康至关重要.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 环境暴露越来越多地与女性生殖功能障碍有关.
- 重金属 (,,,,) 和微量元素 (,铜,) 可以通过内分泌干扰,氧化应激和表观遗传变化影响生育.
- 对金属和元素联合暴露对女性生育能力的综合评估是有限的.
研究的目的:
- 批判性地评估和系统地分析有关重金属和微量元素暴露与生殖年龄妇女生殖健康问题的相关性的流行病学数据.
主要方法:
- 在主要数据库 (PubMed,Scopus,Google Scholar,Web of Science) 中对2010年至2024年间发表的研究进行了全面的文献搜索.
- 包括观察性人类研究,检查金属暴露与女性生殖结果之间的相关性.
- 通过使用纽卡斯尔-太华尺度 (NOS) 评估研究质量,并遵循PRISMA指南.
主要成果:
- 包括23项研究 (11个病例控制,8个横截面,3个队列,1个分析).
- 较高的,和水平与PCOS和子宫内膜异位症的风险增加有关.
- 低和水平与子宫内膜疾病和卵巢储备减少有关.
结论:
- 暴露于危险金属是女性生殖健康的重要,可修改的风险因素.
- 为了保持生殖功能,平衡有害金属与必不可少的微量元素,如和,至关重要.
- 需要进一步的前性和机制性研究来了解剂量反应关系,协同效应和治疗策略.
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