附甲状腺瘤中,法辛表达与侵略性的临床病理特征有关
Yoko Omi1, Tomoko Yamamoto2, Yoji Nagashima3
1Department of Endocrine Surgery, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan; Department of Endocrine Surgery, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
作为一种actin捆绑蛋白质的fascin在具有攻击性的甲状腺瘤中表达更高,包括非典型瘤和癌症. 它在复发病例中的存在表明它与恶性瘤和副甲状腺瘤的不良预后有关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子病理学分子病理学
背景情况:
- 副甲状腺瘤被分为腺瘤,非典型瘤或癌瘤.
- 帕拉纤维素的损失和高Ki-67指数是已知的恶性瘤标志物.
- 甲状腺瘤进展中的fascin作用尚未被探索.
研究的目的:
- 为了研究各种副甲状腺瘤亚型中的魅力表达.
- 为了将魅力表达与纤维素损失和Ki-67指数相关联.
- 评估法辛与侵略性临床病理特征的关联.
主要方法:
- 免疫组织化学被用来评估法斯,纤维素和Ki-67的表达.
- 在19种癌瘤,16种非典型瘤,23种腺瘤和14种正常副甲状腺组织中分析了法辛表达.
- 统计分析将魅力表达与临床病理学数据相关联.
主要成果:
- 与腺瘤 (21.7%) 和正常组织 (0%) 相比,非典型瘤 (50.0%) 和癌症 (42.1%) 的Fascin阳性显著更高.
- 帕斯辛表达与类纤维素损失相关 (p = 0.0071),但与Ki-67指数无关.
- 所有复发的甲状腺瘤都表现出惊人的阳性,纤维素损失和Ki-67指数>5%.
结论:
- 在侵袭性副甲状腺瘤 (非典型和癌症) 中,法辛表达升高.
- 法斯与不良的临床病理特征有关,包括复发.
- 法斯显示出作为甲状腺瘤恶性瘤的生物标志物的潜力.
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