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双极性疾病中的大脑年龄:模型选择和临床因素的影响
Natasha Topolski1, Ercole J Barsotti2, Andrea Boscutti3
1Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, (UTHealth), 77054, Houston, TX, USA; Center of Excellence in Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, 77054, Houston, TX, USA; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 77054, Houston, TX, USA.
双极性障碍 (BD) 与加速的大脑衰老有关,在各种模型中,大脑年龄高于时间年龄. 治疗可能提供神经保护,减少这种大脑年龄差距.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 双极性障碍 (BD) 与加速衰老有关.
- 之前在BD中进行的大脑年龄研究显示了不一致的结果,可能是由于方法的变化.
研究的目的:
- 为了比较三种脑年龄模型,BD型I患者与对照人群进行比较.
- 为了研究药物,特别是,对BD中的大脑年龄的影响.
主要方法:
- 分析了352名BD I型患者和327名对照者的T1加权MRI扫描.
- 三种模型 (ENIGMA,PyBrainAge,Pyment) 计算了预测年龄差异 (PAD).
- 线性混合效应模型控制年龄,性别,扫描仪和药物状态.
主要成果:
- 与所有模型中的对照组相比,BD中PAD升高 (3.03-1.43年更高).
- thalamic和心室体积是BD中PAD升高的关键因素.
- 用治疗的BD患者没有PAD升高;非用户的PAD显著更高.
结论:
- 研究结果支持BD中大脑年龄升高,并表明的神经保护作用.
- 大脑年龄预测受使用的模型,MRI扫描仪和药物状态的影响.
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