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针对FAPα/Integrin αvβ1复合体减弱肝星细胞激活和肝纤维化

Chun Guan1, Nuo Cheng1, Yu Tong1

  • 1State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, PR China.

Biochemical pharmacology
|February 13, 2026
PubMed
概括

在肝星细胞 (HSC) 中抑制纤维细胞激活蛋白α (FAPα) 和整体蛋白αvβ1 抑制肝纤维化. 这种FAPα/Integrin αvβ1复合体针对GPC3/FGF21轴,提供了一个新的治疗策略.

关键词:
组合疗法是一种联合疗法.FAPα是指FAPα的一种类型.肝脏的星状细胞是什么集成的αv1β1β1β1β1β1β1β1β1β1β1β1β1β1β1β1β1β1β1β1肝脏纤维化 肝脏纤维化

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