5-甲诱导的肠粘膜炎:病变发生和潜在的治疗干预措施
Sen-Lin Li1, Dao-Chun Xiang2, Ping Gao3
1Institute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.
Biochemical pharmacology
|February 13, 2026
概括
5-甲 (5-FU) 化疗会引起肠道粘膜炎,导致严重的症状和治疗并发症. 本综述探讨了FIM机制和潜在的干预措施,以改善患者的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠道粘膜炎是5-甲 (5-FU) 化疗的常见和严重毒性.
- 它影响高达80%的患者,导致衰弱的症状,如腹和体重减轻.
- 这些症状可能需要降低剂量或停止治疗,从而对患者的预后和生活质量产生负面影响.
研究的目的:
- 审查5-FU诱导的肠粘膜炎 (FIM) 的复杂机制.
- 探索有助于FIM病原发生的新兴因素.
- 总结FIM管理的潜在药理学策略.
主要方法:
- 对5-FU诱导的肠粘膜炎的机制和干预措施的文献综述.
- 综合目前对FIM病原学的理解.
- 潜在治疗点的识别和总结.
主要成果:
- FIM涉及直接的上皮细胞亡,氧化应激,炎症和屏障破坏.
- 神经调节受损和肠道衰老是FIM的新发现的贡献者.
- 多个分子通路都与FIM发展有关.
结论:
- 了解FIM的多阶段病原性对于开发有效治疗方法至关重要.
- 针对已识别的机制和新型因素可能会减轻5-FU的毒性.
- 这一综述为未来的研究和临床应用在FIM管理方面提供了基础.
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