激活的阿尔及利亚本托尼特具有改善的表面性能和局部屏障性能
Rania Chebani1, Khedidja Tahar Djebbar2, Kamel Daoud1
1Laboratory of Transfer Phenomena, Department of Pharmaceutical and Environmental Engineering, Faculty of Mechanical and Process Engineering, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111, Algiers, Algeria.
的激活将阿尔及利亚的本托尼特粘土转化为局部剂. 这种增强的粘土在体内表现出显著的抗炎和皮肤屏障修复特性,使其成为皮肤治疗的有希望的辅助剂.
科学领域:
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
- 粘土科学 粘土科学
背景情况:
- 阿尔及利亚本托尼特的利用不足.
- 炎症性皮肤疾病需要有效的局部治疗.
- 开发新的局部辅助剂对于障碍修复至关重要.
研究的目的:
- 研究用于局部屏障应用的阿尔及利亚土石的激活.
- 评估活性粘土的矿物学,纹理和界面特性.
- 在炎症性皮肤模型中评估活化粘土的体内性能.
主要方法:
- 净化和激活阿尔及利亚本托尼特.
- 矿物学,纹理和界面属性的表征 (SSA,CEC,pHPZC, ζ-潜在).
- 在体内评估使用刺激性接触性皮肤炎模型 (克罗顿油诱导的耳朵) 和急性皮肤毒性研究.
主要成果:
- 激活产生了富含蒙莫里隆的粘土 (MEA5),增加了SSA和CEC.
- 在皮肤相关的pH值下,MEA5表现出增强的胀,分散和体稳定性,具有稳定的负z电位.
- 在体内,MEA5显示显著减少胀,与印米他辛可比,在毒性研究中耐受性良好.
结论:
- 激活有效地改变了本托尼特用于局部使用的特性.
- MEA5显示出对受损皮肤有前途的屏障形成和抗炎作用.
- 激活的托尼特 (MEA5) 是炎症和受损皮肤配方的潜在局部辅助剂.
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