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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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减弱层A-Prohibitin2相互作用导致在LMNA 289 A>G介导的扩展性心肌病中线粒体功能障碍

Subhradip Nath1, Debasish Prusty1, Sk Ramiz Islam1

  • 1Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata -700064, India; Homi Bhabha National Institute, Mumbai - 400094, India.

The Journal of biological chemistry
|February 13, 2026
PubMed
概括

层A K97E突变破坏了线粒体功能和细胞能量生产,导致严重的扩展性心肌病 (DCM). 这项研究揭示了一种新的机制,它将层A与DCM中的生物能和机械传导联系起来.

关键词:
心筋病变是一种心脏病变.拉米兰 (Lamin) 拉米兰 (Lamin) 是一个机械转导是指机械转导的过程.线粒体中的线粒体.禁止了蛋白质的使用.

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