相关实验视频
Updated: Feb 15, 2026

06:44
3D Printing - Evaluating Particle Emissions of a 3D Printing Pen
Published on: October 9, 2020
9.1K
半固体挤出 (SSE) 3D打印药物制剂的配方和评估,使用波洛克萨默和聚乙烯氧化物作为共同打印的载体聚合物
Kristiine Roostar1, Oleh Koshovyi1, Ivo Laidmäe1
1Institute of Pharmacy, Faculty of Medicine, University of Tartu, 1 Nooruse St, Tartu 50411, Estonia.
概括
与聚乙烯氧化物 (PEO) 结合的Poloxamer F108是半固体挤出 (SSE) 3D打印乙酸 (ASA) 剂型的理想选择,为个性化医疗提供良好的打印能力和可控的药物释放.
科学领域:
- 制药技术 制药技术 制药技术
- 3D打印应用 3D打印应用
- 材料科学 材料科学 材料科学
背景情况:
- 半固体挤出 (SSE) 3D打印使个性化制药剂量形式成为可能.
- 波洛克萨默和聚乙烯氧化物 (PEO) 是制药配方中的关键辅助剂.
研究的目的:
- 为了研究不同级别的Poloxamer (F68,F87,F108) 与PEO相结合的适合性,用于制药SSE3D打印.
- 为了评估波洛克萨默等级对酸 (ASA) 装载剂型的物理化学性质,可打印性和体外药物释放的影响.
主要方法:
- 两种波洛克萨默和PEO (55:45重量/重量) 的二元混合物被制成水性凝.
- 乙盐酸 (ASA) 被纳入了5%,7%和9% (w/w) 的度.
- 通过SSE 3D打印创建了4x4网格和轴孔平板,随后进行了特性表征和体外药物释放.
主要成果:
- 波洛克萨默F108形成了适合SSE3D打印的高粘度凝,而F68和F87显示打印保真度降低.
- FTIR光谱学证实了ASA,PEO和所有波洛克萨默等级的兼容性.
- 通过SSE3D打印的网格表现出即时释放的行为,药物释放率依次为F87 > F68 > F108.
结论:
- 当与PEO结合时,Poloxamer F108是SSE 3D打印ASA装载剂型的最可行的载体聚合物.
- 开发的poloxamer-PEO配方为立即释放口服药物制剂的水性SSE3D打印提供了一个可行的平台.
- 这种方法支持通过先进的3D打印技术来个性化医疗和复合设置.
相关概念视频
Electron Carriers
92.2K
Electron carriers can be thought of as electron shuttles. These compounds can easily accept electrons (i.e., be reduced) or lose them (i.e., be oxidized). They play an essential role in energy production because cellular respiration is contingent on the flow of electrons.
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
92.2K
Polymers
41.4K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
41.4K
Site-Targeted Drug Delivery Systems: Polymeric Carriers
16
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
16
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
4
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
4
Molecular and Ionic Solids
20.3K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.3K
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
6.3K
Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
6.3K

