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队列概况:尼日利亚的婴儿肠道细菌研究 (INBUGS-NG)
Chinenye Pascaline Akpulu1,2, Hafsat Maikudi Sada3, Hafsat Ahmed3
1University of Oxford, Oxford, UK chinenye.akpulu@linacre.ox.ac.uk.
BMJ open
|February 13, 2026
概括
尼日利亚的婴儿肠道细菌研究 (INBUGS-NG) 探讨了早期生活因素如何影响婴儿肠道微生物组和抗生素耐药性基因 (ARG). 观察到高比例的母亲使用抗生素和低排他性母乳养,影响婴儿肠道健康.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 早期的肠道微生物群对婴儿健康和免疫发育至关重要.
- 了解影响肠道微生物组合和抗生素耐药性基因 (ARG) 获取的因素至关重要,特别是在不同的环境中.
- 尼日利亚的婴儿肠道细菌研究 (INBUGS-NG) 解决了非洲婴儿肠道微生物组研究的知识差距.
研究的目的:
- 调查分娩方式,抗生素暴露,养习惯和环境因素对婴儿肠道微生物组发展的影响.
- 描述尼日利亚北部婴儿在生命的第一年内获得抗生素耐药性基因 (ARG) 的特征.
- 从非洲婴儿群体中建立一个独特的元基因组资源.
主要方法:
- 在尼日利亚的卡诺,对90个母婴双胞胎进行了前性的纵向队列研究.
- 在10个时间点进行密集的便采样,以及母乳直肠抽样,母乳和环境样本.
- 使用REDCap和家庭日记收集社会人口统计,临床和文化数据.
- 使用长时间读取的中基因组测序 (牛津纳米孔) 进行菌株级和等离子体级别的分析.
主要成果:
- 产后抗生素使用在母亲 (93.3%) 和婴儿早期抗生素暴露 (28.9%在3个月内) 的高患病率.
- 纯母乳养率低 (8%),常见的早期补充水.
- 剖腹产分娩占所有分娩的25%;平均妊娠年龄为38.5周.
- 成功保留队列并生成一个独特的长时间读取的元基因组数据集.
结论:
- 早期的暴露,包括高抗生素使用和低于最佳的养做法,显著塑造了尼日利亚北部的婴儿肠道微生物组和ARG景观.
- INBUGS-NG研究为了解非洲背景下的婴儿肠道微生物组动态提供了宝贵的资源.
- 进一步的分析将探索暴露与抵抗体动态之间的关联,并有可能进行跨队列比较.
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