心脏功能和前列腺癌风险和预后:PROCA-Life研究
Martin Støyten1, Tore Knutsen2, Inger Thune3
1Department of Clinical Medicine, UIT- The Arctic University, Tromsø, Norway; Department of Anesthesiology, University Hospital of North Norway, Tromsø, Norway.
Clinical genitourinary cancer
|February 13, 2026
概括
心脏功能,特别是腹功能障碍,与前列腺癌 (PCa) 风险和死亡率的增加有关. 早期发现心脏功能异常可能会改善PCa男性的结果.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PCa) 的风险和心血管疾病 (CVD) 的负担随着年龄的增长而增加.
- 了解心脏功能和PCa之间的关系对于风险评估和预后至关重要.
研究的目的:
- 研究前诊断性心脏功能与前列腺癌的风险和预后之间的关联.
- 评估心声回声学参数与PCa发展和结果之间的相互作用.
主要方法:
- 利用了前列腺癌终身研究 (PROCA-life) 队列的数据,其中包括来自特罗姆索研究的2514名男性.
- 采用心声回声检查和Cox比例危险模型来分析心脏功能和PCa风险/死亡率之间的关联.
- 从1994年到2016年,对参与者进行了跟踪,其中235名男性被诊断患有PCa.
主要成果:
- 60.3岁以上的男性有异常的头骨峰值E减速时间 (DT) (<140毫秒或>220毫秒) 显示高风险/转移性PCa的概率是1.66-3.37倍.
- 在PCa患者中,异常的DT (低或高) 与与正常DT相比显著更高的整体死亡率有关.
- DT>220毫秒与2.09倍高的PCa特定死亡率有关.
结论:
- 预诊断的扩张性功能障碍与高风险/转移性PCa的风险增加有关.
- 心脏功能异常预测了更高的整体和PCa特定死亡率.
- 对于被诊断患有前列腺癌的男性来说,心血管监测至关重要.
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