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产前暴露于极端高温和儿童自闭症
David G Luglio1, Xin Yu2, Jane C Lin3
1Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70118, USA.
The Science of the total environment
|February 13, 2026
概括
怀孕早期和晚期夜间高温与儿童自闭症风险增加有关. 鉴于全球气温上升,这一发现令人担忧,并要求对温度进行进一步调查.
科学领域:
- 环境流行病学环境流行病学
- 神经发育障碍 神经发育障碍
- 气候变化影响 气候变化影响
背景情况:
- 全球气温上升与不良的神经发育结果有关.
- 对自闭症谱系障碍 (ASD) 的产前危险因素越来越多地得到认可.
- 孕期温度对自闭症发展的影响以前没有被研究过.
研究的目的:
- 研究妊娠期温度变化与儿童自闭症发展风险之间的关联.
- 确定与自闭症相关的产前温度暴露的关键窗口.
主要方法:
- 一项回顾性出生队列研究,对2001年至2014年间出生的294937名儿童进行了回顾性研究.
- 利用电子医疗记录来识别5岁时的自闭症诊断.
- 估计每周最大 (Tmax) 和最小 (Tmin) 温度使用 gridMET 模型在孕产妇住所.
- 用Cox的比例危险模型与非线性分布的滞后来评估温度-自闭症风险.
主要成果:
- 在怀孕早期 (1-10周) 和晚期 (30-37周) 暴露于极端夜间最低温度 (Tmin) 与自闭症风险增加有关.
- 在第99个百分点和第50个百分点对Tmin暴露的危险比率 (95% CI) 是1.154 (1.040,1.288) 在第1-10周和1.132 (1.030,1.246) 在第30-37周.
- 在白天最高温度 (Tmax) 和自闭症风险之间没有发现显著的关联.
结论:
- 在特定的早期和晚期怀孕期间,夜间温度升高与儿童患自闭症的风险更高有关.
- 这些发现凸显了气候变化对神经发育结果的潜在影响.
- 需要进一步的研究来阐明Tmin关联和Tmax关联的缺失背后的机制.
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