前列腺癌治疗与肌肉结构的变化之间的关系:系统性审查
L Partridge1, A Vickers2, D McSweeney2
1School of Medical Sciences, University of Manchester, Manchester, UK.
概括
前列腺癌的雄激素剥夺疗法和放射治疗可能会影响肌肉质量,可能会增加非癌症死亡风险. 需要进一步的研究来定义肉类症和指导干预措施,以获得更好的生存结果.
科学领域:
- 在瘤学瘤学.
- 老年学是指老年学的学科.
- 辐射疗法 辐射疗法
背景情况:
- 前列腺癌 (PCa) 治疗方法,如雄激素剥夺疗法 (ADT) 和放射疗法 (RT) 用于治疗意图.
- 这些治疗对患者肌肉和随后的生存结果的影响需要进一步研究.
研究的目的:
- 系统地审查ADT和RT对PCa男性肌肉结构的影响.
- 确定这些肌肉变化是否影响死亡率和无进展生存率.
主要方法:
- 在Embase和Medline (2014-2024) 上进行了系统的文献搜索.
- 研究遵循PRISMA指南,并使用NIH质量评估工具评估偏差.
- 八项研究符合叙事综合的纳入标准,共计1176名患者.
主要成果:
- 一些研究表明PCa治疗,肌肉和结果之间存在显著联系.
- 骨肌指数 (SMI) 的1%下降与非癌症死亡率的9%增加有关.
- 强调需要一致的石症定义和更多关于肌肉生存关联的研究.
结论:
- 不一致的sarcopenia定义限制了研究的可比性和通用性.
- 肌肉变化与ADT/RT之间的联系凸显了 Sarcopenia查的重要性.
- 缺乏确定的最佳实践,以干预减轻与肌肉衰退相关的风险.
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