密度重置对前列腺MR导向适应性放射治疗治疗计划的剂量计影响
Carson Matthews1, Sotirios Stathakis2, Krystal Kirby2
1Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70820, USA.
概括
这项研究发现,在Elekta Unity系统的磁共振引导自适应放射治疗 (MRgART) 计划中,散密度覆盖 (BDOs) 引入了微小的剂量计不确定性,主要是在直肠等区域,但不会显著影响关键的 QUANTEC 剂量指标.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 放射治疗技术 放射治疗技术
背景情况:
- 使用MR导向线性加速器 (MR-LINACs) 的自适应性辐射疗法 (ART) 可使每天的治疗适应.
- 在适应性规划中,批量密度覆盖 (BDO) 估计了电子密度 (ED),与CT相比可能导致剂量计不确定性.
- 准确的剂量计算对于安全有效的MR导向适应性放射治疗 (MRgART) 是至关重要的.
研究的目的:
- 评估和量化基于BDO和基于CT的前列腺治疗计划之间的剂量差异MRgART.
- 评估BDOs对摩纳哥治疗计划系统 (TPS) 中剂量体积组图 (DVH) 指标的影响.
主要方法:
- 对21名前列腺VMAT患者的回顾性分析.
- 使用机构CT-to-ED表将CT数字转换为ED.
- 使用基线和QUANTEC DVH指标,比较基于BDO的计划与基于CT的参考计划的剂量分布.
主要成果:
- 由于BDOs,在基线DVH指标中观察到局部剂量差异高达9% (例如,直肠的D50%).
- 在 QUANTEC DVH 度量或前列腺平均剂量方面没有发现显著差异 (>1%).
- 前列腺的平均平均剂量差异为0.6%,没有其他轮体积超过1.0%的平均剂量差异.
结论:
- 在Elekta Unity/摩纳哥工作流程中,BDO对MRgART具有临床可行性.
- 与BDO的局部剂量测量差异不会显著影响关键的QUANTEC DVH指标.
- 由于系统特定的变化,建议在不同的TPS平台上进行进一步评估.
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