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睡眠特征与健康因素和肠道微生物群的相互作用
Jiafei Wu1, Sergio Andreu-Sánchez1,2, Haoran Peng1
1Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Nature communications
|February 13, 2026
概括
睡眠质量差和社交时差与下肠道微生物群多样性有关. 某些肠道细菌可能会影响饮食如何影响睡眠,这表明微生物组干预可以改善睡眠.
科学领域:
- 微生物组研究的研究.
- 睡眠科学 睡眠科学
- 营养科学 营养科学
背景情况:
- 越来越多的证据表明,睡眠模式和肠道微生物群之间存在复杂的相互作用.
- 了解这些联系对于制定整体健康策略至关重要.
研究的目的:
- 研究睡眠特征 (质量,时间型,社会时差) 与肠道微生物组组成之间的关联.
- 探索生活方式因素 (包括饮食) 在睡眠与微生物组关系中的作用.
- 为了确定可能调解饮食对睡眠影响的特定细菌物种.
主要方法:
- 对6941名"生命线"荷兰微生物组项目参与者的肠道微生物组组成和睡眠数据的分析.
- 统计分析以评估α和β多样性与睡眠参数之间的相关性.
- 在一个独立的队列中验证与睡眠相关的细菌物种.
- 调解分析是为了探索饮食,微生物组和睡眠之间的因果关系.
主要成果:
- 较低的α多样性与较差的睡眠质量,较晚的时间型和增加的社交时差相关.
- 贝塔多样性与睡眠质量和社交时差有关.
- 137种细菌被发现与睡眠有关,其中35.6%被独立验证.
- 调解分析表明,虽然睡眠影响微生物群,但特定物种 (例如,Clostridia UC5_1_1E11,SGB14844) 调解饮食对社会时差 (例如,咖啡摄入) 的影响.
结论:
- 肠道微生物组和睡眠表现出双向关系,受饮食等生活方式因素的影响.
- 特定的肠道微生物组成与睡眠质量和时间有关.
- 针对微生物组的干预措施有可能通过调节饮食-微生物组-睡眠轴来改善睡眠健康.
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