关于自身免疫性视神经炎的诊断和分类的发展和挑战的最新情况
Murat Delikaya1,2, Roua Hamdi1,2, Charlotte Bereuter1,2
1Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
准确诊断自身免疫性视神经炎 (ON) 对于有效治疗至关重要. 这篇评论强调了临床症状,神经眼科评估以及人工智能和生物标志物等先进工具,以精确地确定ON亚型.
科学领域:
- 神经眼科神经眼科
- 自免疫神经学 自免疫神经学
- 诊断成像诊断成像的使用
背景情况:
- 自身免疫性视觉神经炎 (ON) 涵盖多种疾病,包括多发性硬化症 (MS),视觉神经炎光谱障碍 (NMOSD) 和MOGAD.
- 早期和准确的ON诊断至关重要,因为治疗策略在亚型之间有很大差异.
研究的目的:
- 综合当前关于诊断自身免疫性视神经炎的知识.
- 审查临床症状,神经眼科评估和用于ON诊断的临床准工具.
- 解决诊断挑战,并概述包括人工智能应用在内的未来方向.
主要方法:
- 在PubMed/MEDLINE (2000-2025) 的文献综述中,强调了最近的研究.
- 对关键共识标准和里程碑性研究进行选.
- 包括成像,电生理学和流体生物标志物的数据.
主要成果:
- 讨论临床红旗和结构化的神经眼科评估.
- 对临床工具的评估:MRI,抗体测定,OCT,VEP.
- 识别诊断灰色区域,实施障碍和人工智能应用.
结论:
- 集成MRI,抗体检测,OCT和VEP的标准化诊断途径对于现实世界的改善至关重要.
- 液体生物标志物 (sNfL,sGFAP) 和人工智能分析可以完善风险分层,特别是在血清阴性病例中.
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