淋巴结转移的临床特征和风险分析cN0分化甲状腺癌患者的淋巴结转移
Meng Wei1, Kaipeng Hu2, Gaolin Qiu3
1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Scientific reports
|February 13, 2026
概括
年轻的年龄,男性性别,较高的瘤直径和特定的血液标记物,如RET融合,前列血时间活性 (PT%) 和白细胞 (WBC) 计数与分化甲状腺癌患者的淋巴结转移有关,这些患者最初被分类为临床淋巴结阴性 (cN0).
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 分化甲状腺癌 (DTC) 是最常见的甲状腺恶性瘤.
- 精确评估淋巴结转移 (LNM) 对于DTC的分期和治疗计划至关重要.
- 临床上淋巴结阴性 (cN0) 患者小瘤 (0.5-3.0厘米) 需要仔细评估潜在的LNM.
研究的目的:
- 在临床淋巴结阴性 (cN0) 差异化甲状腺癌 (DTC) 患者中研究与淋巴结转移 (LNM) 相关的临床特征.
- 在这个特定的患者队列中确定LNM的预测因素.
主要方法:
- 对232名cN0 DTC患者的临床数据的回顾性分析,这些患者接受了激进甲状腺切除术.
- 纳入标准:瘤直径>0.5厘米和<3.0厘米.
- 基于年龄,性别,瘤特征,超声检测结果 (TI-RADS),RET融合状态,多焦点性,甲状腺刺激激素 (TSH),前血红蛋白时间活性 (PT%),白细胞 (WBC) 数量,BMI,血液尿素和甲状腺激素水平 (T3,T4) 的基础上,进行统计分析来比较LNM阳性和LNM阴性组.
主要成果:
- 阳性LNM组较年轻 (40.9岁对45.3岁),男性比例较高 (P=0.0436).
- 在LNM阳性组中观察到更高的TI-RADS得分 (p<0.001),更大的最大瘤直径 (1.11对0.808厘米,P=0.0034),以及RET融合频率增加 (16.3%对2.7%,P=0.0026).
- 在两组之间的PT% (P=0.034) 和WBC数量 (P=0.0495) 中发现了统计学上显著的差异.
- 在BMI,血液尿素,PT%,甲状腺激素水平 (T3,T4) 之间发现了新的相关性.
结论:
- 包括年轻年龄,男性性别,较大的瘤直径,RET融合,升高的PT%和改变的白细胞计数在内的因素与cN0 DTC患者的LNM有关.
- 这些发现强调了考虑这些临床和实验室参数的重要性,超出了初始成像,以准确地分层风险.
- 需要进一步的研究来探索DTC中PT%,BMI,血液尿素和甲状腺激素水平之间的新发现的相关性.
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