亨特研究确定了与人类肠道微生物群组成重复相关的宿主遗传因素
Marta Riise Moksnes1, Eivind Coward2, Maria Nethander3
1Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. marta.r.moksnes@ntnu.no.
Nature genetics
|February 13, 2026
概括
宿主基因显著影响肠道微生物群的组成,影响人类健康和疾病. 这项研究发现了与肠道细菌的新型遗传联系,可能会影响诸如乳等疾病.
科学领域:
- 人类遗传学 人类遗传学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 肠道微生物群在人类健康和疾病中起着至关重要的作用.
- 了解宿主基因对肠道微生物群组成的影响对于阐明疾病机制至关重要.
研究的目的:
- 进行全基因组关联研究 (GWAS),以确定影响肠道微生物群组成的宿主遗传因素.
- 在独立的北欧队列中复制识别的协会.
- 探索宿主遗传,肠道微生物群和特定疾病之间的联系.
主要方法:
- 来自特伦德拉格健康研究 (HUNT) 的12,652名个体的全基因组关联研究 (GWAS).
- 对来自北欧群体的16,017-21,976个人进行复制分析.
- 单核酸多态 (SNP) - 种类关联和功能模块的遗传信号的识别.
- 后续分析和门德尔随机化 (MR) 来评估因果关系.
主要成果:
- 在6个基因组位置中确定了12个可复制的SNP物种关联,包括已知的 (LCT, ABO) 和新鲜的 (HLA-DQB1,MUC12,SLC37A2,FUT2) 区域.
- 在三个位置 (LCT,ABO,FUT2) 检测到与肠道微生物群功能模块相关的遗传信号.
- 宿主-微生物群的关联与乳病和出血病的发病.
- MR 分析证实了体重指数对肠道微生物群组成的因果关系.
结论:
- 宿主基因在塑造肠道微生物群组成方面发挥着重要作用.
- 已经确定了影响肠道微生物群的新型遗传位置.
- 这些宿主微生物群相互作用与特定疾病的发病有关,并受到BMI等因素的影响.
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