全基因组关联分析强调了肠道分子环境在人类肠道微生物群变异中的作用
Koen F Dekkers1, Kamalita Pertiwi1, Gabriel Baldanzi1
1Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Nature genetics
|February 13, 2026
概括
人类遗传变异显著影响肠道微生物组合. 这项研究确定了与特定细菌物种和胃肠功能相关的新遗传基因位点,进步了我们对宿主微生物相互作用的理解.
科学领域:
- 人类遗传学 人类遗传学
- 微生物组研究的研究.
- 人口基因组学是人口的基因组学.
背景情况:
- 肠道微生物群对健康至关重要,但人类遗传变异对其组成的影响尚不清楚.
- 研究肠道微生物组的遗传基础对于理解宿主微生物相互作用及其对健康的影响至关重要.
研究的目的:
- 为了识别与肠道微生物组成相关的人类遗传变异.
- 探索宿主基因与特定细菌物种和胃肠功能之间的关系.
主要方法:
- 基因组范围的关联分析是对来自多个基于人口的多项研究中的28000多名个体的协调后代基因组数据进行的.
- 使用挪威HUNT研究的数据进行了复制分析.
- 用代谢学和基因表达数据来支持遗传发现.
主要成果:
- 在OR51E1-OR51E2位点中确定了与微生物丰富相关的遗传变异.
- 发现了15个显著的遗传关联 (P <5.4 × 10-11),涉及8个位点和14种细菌物种,其中11个关联被复制.
- 在LCT,ABO和FUT2位点确认已知的关联,并确定了包括MUC12,CORO7-HMOX2,SLC5A11,FOXP1和FUT3-FUT6.6在内的新型位点.
结论:
- 人类遗传变异在塑造肠道微生物组成方面发挥着重要作用.
- 这些发现将遗传因素与胃肠功能联系起来,例如脂肪酸感应,胆汁成分和粘膜层完整性.
- 这项研究为肠道微生物组的遗传结构及其功能后果提供了新的见解.
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