对症状概况的动态网络分析及其对接受术后辅助化疗的结肠直肠癌患者的预期影响
Langjuan Li1,2, Wangjie Xia3,4, Daoxia Guo4
1First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
概括
化疗的副作用,如味道变化和昏昏欲睡,对患者有很大的影响. 早期识别这些关键症状可以帮助控制结肠直肠癌患者的整体症状负担.
科学领域:
- 在瘤学瘤学.
- 症状科学 症状科学
- 网络分析 网络分析
背景情况:
- 化疗经常导致患者的不良副作用.
- 了解症状之间的相互作用对于患者护理至关重要.
- 动态网络分析为治疗期间的症状动态提供了洞察力.
研究的目的:
- 分析化疗引起的症状之间的动态相关性.
- 在结直肠癌 (CRC) 患者的不同治疗阶段确定关键预测症状.
- 为了澄清特定症状对整体症状负担的影响.
主要方法:
- 一项涉及380名结直肠癌患者的纵向研究.
- 在早期,中期和晚期化疗阶段使用纪念症状评估量表 (MSAS-C) 评估症状.
- 交叉滞后小组网络 (CLPN) 分析以建模动态症状关系并识别影响性症状 (超出预期的影响,超出EI;超出预期的影响,在EI).
主要成果:
- 从早期到中期,口味变化是主要预测因素 (out-EI=0.846).
- 从中期到后期阶段,嗜睡成为核心预测因素 (out-EI=0.713).
- 肢体麻木/刺痛显示出最高的IE,这表明它经常被其他症状预测出来.
- 高度预测性症状显著影响了晚期症状负担 (P < 0.001).
结论:
- 在早期化疗中专注于味道变化,以减轻下游效应.
- 在治疗的中间阶段优先评估昏昏欲睡.
- 调查导致手和脚麻木/的因素,以有效地管理患者的不适.
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