检查酸脱酶抑制剂对人类安全性测试的彻底性:fluopyram作为一个案例研究
Kim Z Travis1, Rémi Bars2,3, Helen Tinwell4
1Regulatory Science Associates, Largs Yacht Haven, Irvine Road, Largs, KA30 8EZ, UK. kim.travis@regulatoryscience.com.
Archives of toxicology
|February 13, 2026
概括
这项研究发现,尽管存在担忧,但杀菌剂fluopyram不会抑制人类的糖酸脱酶. 在动物研究中观察到的毒性与这种酶无关,也与人类健康无关.
科学领域:
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
- 杀菌剂安全性 杀菌剂安全性
背景情况:
- 人们担心,酸盐脱酶抑制剂 (SDHI) 杀菌剂可能会抑制人类的酸盐脱酶,造成健康风险.
- 监管研究可能忽略了SDHI对这种酶的影响.
研究的目的:
- 批判性地评估SDHI真菌杀菌剂fluopyram对人类的安全性研究.
- 为了确定皮拉姆是否抑制人体糖酸脱酶,并研究其观察到的毒性机制.
主要方法:
- 对跨物种 (老鼠,小鼠,狗) 和暴露持续时间的皮拉姆毒性研究的全面审查.
- 检查机械学研究以确定毒性原因.
- 评估潜在的糖酸脱酶抑制及其后果.
主要成果:
- 皮拉姆在动物模型中的主要毒性涉及肝脏,甲状腺和脏 (老年雄性大鼠).
- 这些效应在机理上与糖酸脱酶抑制有区别,与人类无关.
- 对敏感组织 (神经系统,心脏,肌肉) 进行了广泛的显微镜检查,没有发现任何影响,表明没有糖酸脱酶抑制.
结论:
- 皮拉姆不抑制人类的糖酸脱酶.
- 观察到的动物毒性与糖酸脱酶抑制无关,也不构成人类健康风险.
- 对哺乳动物酸脱酶和快速新陈代谢的低亲和力解释了这些发现.
相关概念视频
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Survey Safety
421
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
421
Eukaryotic Transcription Inhibitors
11.1K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.1K
Serum Studies: Renal Function Tests
462
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
462
Household Wiring And Electrical Safety
1.7K
Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K


