Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cascaded Op Amps01:16

Cascaded Op Amps

1.2K
Operational amplifiers (op-amps) are versatile electronic components that can be interconnected in a cascade - one after another in a linear sequence. This cascading is possible due to their infinite input resistance and zero output resistance, allowing them to maintain their input-output relationships even when connected in series.
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
1.2K
Second-order Op Amp Circuits01:19

Second-order Op Amp Circuits

647
Implementing second-order low-pass filters in audio systems is crucial in refining audio signals by eliminating undesirable high-frequency noise. These filters typically involve second-order op-amp circuits configured as voltage followers, encompassing two nodes with distinct storage elements.
The analysis of such circuits follows a systematic approach, similar to the second-order RLC circuits. In practical scenarios, bulky inductors are rarely employed due to their size and weight. This means...
647
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

431
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
431
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
Characteristics of Practical Op Amps01:16

Characteristics of Practical Op Amps

881
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
881
Op Amp AC Circuits01:18

Op Amp AC Circuits

512
Within an audio system, the filter circuit plays a pivotal role in processing the amplified audio signal from an amplifier. Its primary function is significantly attenuating signal components with lower frequencies, thereby shaping the audio output. This circuit's operations are examined, focusing on the fundamental filter configuration. This configuration involves an operational amplifier arranged in an inverting setup coupled with resistors (R1 and R2) and a capacitor (C1).
512

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Metabolic imaging for gamete and embryo assessment through advanced microscopy technologies: a novel avenue for artificial intelligence?

Human reproduction (Oxford, England)·2026
Same author

The 2026 global roadmap for textile-integrated wearable technologies in health.

Physiological measurement·2026
Same author

Shotgun metagenomic profiling reveals ecological and functional alterations of the oral microbiome in craniosynostosis.

Journal of oral microbiology·2026
Same author

Deep learning-based segmentation of human oocytes with cross-dataset evaluation.

Computer methods and programs in biomedicine·2026
Same author

Interpretable graph-based models on multimodal biomedical data integration: a technical review and benchmarking.

Nature communications·2026
Same author

From tooth to gut: Proteomic evidence of systemic dysregulation in fluorosis.

Ecotoxicology and environmental safety·2026

相关实验视频

Updated: Feb 15, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci
11:09

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

18.2K

基于ACMG/AMP的变种分类工具的全面评估

Tohid Ghasemnejad1, Yuheng Liang1, Khadijeh Hoda Jahanian2

  • 1UNSW BioMedical Machine Learning Lab (BML), School of Biomedical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia.

Bioinformatics (Oxford, England)
|February 13, 2026
PubMed
概括

本研究比较了用于孟德尔乱的ACMG/AMP变异解释工具. 像LIRICAL和Franklin这样的表型驱动工具在变体优先级方面显示出卓越的准确性.

更多相关视频

A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants
06:35

A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants

Published on: October 10, 2022

2.4K
Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K

相关实验视频

Last Updated: Feb 15, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci
11:09

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

18.2K
A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants
06:35

A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants

Published on: October 10, 2022

2.4K
Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K

科学领域:

  • 基因组医学是基因组医学.
  • 临床生物信息学 临床生物信息学
  • 计算生物学 计算生物学

背景情况:

  • 美国医学遗传学与基因组学学院/分子病理学协会 (ACMG/AMP) 的指导方针是临床变异解释的标准.
  • 缺乏对ACMG/AMP软件工具的比较研究,阻碍了临床采用.
  • 临床医生需要基于证据的指导来选择变异解释工具.

研究的目的:

  • 为了对基于ACMG/AMP的变体解释软件的性能进行比较和比较.
  • 确定在门德尔障碍中优先考虑变异的高性能工具.
  • 为临床医生提供有关选择适合变种分析工具的指导.

主要方法:

  • 与LIRICAL对比四种ACMG/AMP工具 (Franklin,InterVar,TAPES,Genebe) 使用151个由专家策划的门德尔障碍数据集.
  • 根据top-N准确度,保留率,精度,回忆,F1分数和AUC的评估工具.
  • 使用启动信任区间和弗里德曼测试进行统计验证.

主要成果:

  • 在门德尔乱中,LIRICAL (68.21%) 和富兰克林 (61.59%) 显示出卓越的前10个变体优先级准确性.
  • 具有先进表型整合的工具显著优于仅依赖基因组特征的工具.
  • 统计分析证实了LIRICAL和富兰克林 (p<0.0000) 的显著优势表现.

结论:

  • 以表型为驱动的变体解释工具,如LIRICAL和Franklin,对于孟德尔障碍更有效.
  • 该研究为临床医生选择变异解释软件提供了关键数据.
  • 数据和代码的开放可用性确保了可重复性,并促进了进一步的研究.