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Updated: Feb 15, 2026

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肠道细菌的O-脱甲基化调节了系统性暴露于口服埃托胺的情况

Ashutosh Tripathi1, Toe Ein Kyawt2, Jongoh Shin3

  • 1Department of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Gut microbes
|February 13, 2026
PubMed
概括

肠道微生物可以O-脱甲基化药物,改变它们的作用. 这项研究发现64种药物中的35种药物中O-脱甲基化活性,包括埃托,影响其疗效和毒性.

关键词:
我们的肠道微生物群.通过O-脱甲基化.这里是etoposide的位置.药物动力学 药物动力学异生生物代谢的新陈代谢

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