梅瓦隆酸补充剂以增强晚产妇年龄妇女的euploid胚胎形成:随机对照试验的研究方案
Shanshan Wang1,2, Yonghong Zhang1,2, Lingjuan Wang1,2
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.
Trials
|February 14, 2026
概括
这项研究研究了对接受前置植入基因检测 (PGT-A) 的晚年母亲年龄妇女的美瓦酸盐 (MVA) 途径补充. 该试验的目的是提高卵细胞能力,增加euploidy胚胎细胞率,以获得更好的妊娠结果.
科学领域:
- 生殖医学 生殖医学
- 遗传学 遗传学是一种遗传学.
- 细胞生物学 细胞生物学
背景情况:
- 卵细胞动积分有助于晚期孕妇年龄 (AMA) 妇女的怀孕失败.
- 目前的辅助生殖技术在防止与年龄相关的卵细胞质量下降方面取得了有限的成功.
- 梅瓦诺酸 (MVA) 途径在颗粒状细胞中的作用支持卵细胞成熟,但人类的治疗潜力尚未被证明.
研究的目的:
- 评估梅瓦酸盐 (MVA) 补充剂对晚期孕产妇年龄 (AMA) 妇女的卵细胞能力的疗效,这些妇女接受了前植入性遗传测试,以检测血管积分 (PGT-A).
主要方法:
- 一个单中心,前性,随机对照试验,招募了128名年龄在38-42岁之间的不孕妇女接受PGT-A.
- 参与者随机分为MVA补充或控制组.
- 主要结局:欧化母细胞率;次要结局:冷胚胎移植 (FET) 后的临床怀孕和活产率.
主要成果:
- 当研究完成并可获得结果后,该部分应填写.
结论:
- 该试验将评估MVA补充剂对PGT-A接受AMA妇女的euploidy胚胎细胞发育率和临床怀孕结果的影响.
- 这些发现可能会为MVA补充作为该人群的辅助不孕症治疗提供见解.
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