患者衍生有机体模型的方法和应用,用于多种癌症类型的免疫微环境和免疫治疗研究
Yaya Yu1,2,3, Yanan Li4, Jiao Wang4,5
1The Second Clinical Medical College of Guangzhou, University of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. 13580346734@163.com.
Experimental hematology & oncology
|February 14, 2026
概括
患者衍生瘤器官 (PDTO) 模拟瘤微环境 (TME),以改善癌症免疫疗法. 这些3D模型增强了细胞复杂性,有助于开发个性化的治疗方法,并预测治疗疗效.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
背景情况:
- 癌症免疫治疗的一个重大挑战是缺乏准确复制瘤微环境 (TME) 和人类免疫反应的临床前模型.
- 新兴的有机体模型对于推进癌症免疫疗法开发中的精准医学至关重要.
研究的目的:
- 审查用于模拟TME的三维 (3D) 患者衍生瘤器官 (PDTO) 的开发.
- 总结PDTO在研究瘤免疫相互作用和查免疫疗法的方法和应用.
主要方法:
- 在免疫瘤学中利用实验技术和共同培养模型来增强体外模型的复杂性.
- 开发3D患者衍生瘤器官 (PDTO) 来建模瘤微环境 (TME).
- 研究瘤细胞,癌症相关纤维细胞 (CAF) 和免疫细胞 (淋巴细胞和髓状细胞) 之间的相互作用.
主要成果:
- 在体外模型中,PDTO增强了细胞复杂性,改善了免疫疗法开发和生物标志物发现.
- 已经开发了PDTOs模拟TME的方法,以研究瘤-免疫细胞相互作用.
- 总结了PDTO在药理和细胞免疫疗法的个性化查中的应用.
结论:
- PDTO提供了一种全面和个性化的方法来建模瘤免疫生物学.
- 这些模型对于通过捕捉个体瘤免疫相互作用来推进精确免疫疗法至关重要.
- PDTO-免疫共同培养模型是研究人员,临床医生和药物开发人员的重要资源.
相关概念视频
01:27Tumor Immunotherapy
2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
01:18Sampling Methods: Sample Types
3.3K
Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
3.3K
01:38What is the Immune System?
133.1K
Overview
133.1K
02:17The Tumor Microenvironment
7.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.9K
01:08Titrimetric Methods: Types and Commonly Used Strategies
2.6K
In chemistry, titrimetric methods are broadly classified into three types: volumetric, gravimetric, and coulometric. Volumetric titrations involve measuring the volume of a titrant of known concentration that is required to react completely with an analyte. In gravimetric titrations, the standard solution reacts with the analyte to form an insoluble precipitate, which is filtered, dried, and weighed. In coulometric titrations, current is applied to an electrochemical reaction until the reaction...
2.6K
01:36Humoral Immune Responses
84.2K
Overview
84.2K